猫の手術以外の避妊法、米研究チームが開発 増えすぎ防ぐ有望な手段になるか
配信
https://news.yahoo.co.jp/articles/1d722839ebfc933f98c7223114399e8a873e3633
https://www.cnn.co.jp/fringe/35204903.html
（ＣＮＮ） 世界のイエネコの数は推定６億匹。そのうち８０％は野良猫や捨て猫が占める。猫の避妊・去勢をすれば野良猫を減らし、保護施設の過剰負担を軽減し、野鳥や小動物が猫の餌になるリスクを減らすこともできる。そこで米国の研究チームが手術以外の手段を使って長期的に猫の妊娠を防ぐ新たな方法を開発し、６日の科学誌ネイチャー・コミュニケーションズに発表した。
（以下略，詳細はURLを参照）
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【原著論文】
- Article
- Open Access
- Published:
Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene
Nature Communications volume 14, Article number: 3140 (2023)
Abstract
Eighty percent of the estimated 600 million domestic cats in the world are
free-roaming. These cats typically experience suboptimal welfare and inflict
high levels of predation on wildlife. Additionally, euthanasia of healthy animals
in overpopulated shelters raises ethical considerations. While surgical ster-
ilization is the mainstay of pet population control, there is a need for efficient,
safe, and cost-effective permanent contraception alternatives. Herein, we
report evidence that a single intramuscular treatment with an adeno-
associated viral vector delivering an anti-Müllerian hormone transgene pro-
duces long-term contraception in the domestic cat. Treated females are fol-
lowed for over two years, during which transgene expression, anti-transgene
antibodies, and reproductive hormones are monitored. Mating behavior and
reproductive success are measured during two mating studies. Here we show
that ectopic expression of anti-Müllerian hormone does not impair sex ster-
oids nor estrous cycling, but prevents breeding-induced ovulation, resulting in
safe and durable contraception in the female domestic cat.